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The fibrotic burden contributes to systemic inflammation and endothelial dysfunction, which accelerate the development of atherosclerosis and other cardiovascular complications [42,43]

The most frequently reported side effects include: Gastrointestinal issues affect approximately 20% of users, with nausea being the most common Vomiting occurs in about 1 in 10 people during clinical trials [7] Abdominal pain was reported by roughly 1 in 14 patients Constipation affects approximately 1 in 20 users Recent monitoring has shown that some patients may experience mental health-related effects

Statistical analysis Data are expressed as mean standard error of the mean (SEM), unless stated otherwise