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While not entirely novel, having been in development since the 1990s (58)

Generic pre-op forms often only ask about regular medications, which patients skip because: Many do not count weight loss shots as medicine Some feel embarrassed about using weight loss drugs They simply do not know these matter to Anaesthetists AusDoc reported this trend last year in an article Anaesthetists forced to cancel procedures because of patients keeping quiet about GLP-1 receptor agonists

Receptor tolerance is another: sustained GLP-1 stimulation can lead to partial desensitization, reducing the appetite-suppressing effect over time

It's the legal basis for the prescription

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(3) payload-mediated receptor engagement with potential for novel agonist pharmacology (biased signaling, sustained activation) not achievable with a small peptide