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More concerning, though rare, is the risk of acute pancreatitis, which has been reported with GLP-1 receptor agonists and is noted in the Warnings and Precautions sections of the prescribing information

A recent study by Gabery et al, 139 using Semaglutide, revealed that GLP-1RAs could directly access multiple brain nuclei, including the brainstem, septal nucleus, and hypothalamus, but did not cross the BBB

Research published in the Jounal of the American Medical Association (JAMA) found an increased risk of gastroparesis when using GLP-1 drugs like Ozempic and Wegovy

Working through these patterns allows your self-esteem to become less dependent on a number, a clothing size, or a medication, and more grounded in who you are as a whole person

These medications are typically given as injections and have been shown in clinical trials to help people lose significant weight when combined with diet and exercise

In Phase 2a, it achieved up to 1120% body-weight reduction with strong tolerability