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An additional and important caution applies if either agent is used alongside insulin or a sulfonylurea: retatrutide's glucose-lowering activity may increase the risk of hypoglycaemia in this context, and dose review of any existing antidiabetic medicines would be essential before combining treatments

Personalized dosing based on genetic predisposition may be especially valuable during this sensitive life stage

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Any severe or persistent symptoms should be discussed with the prescribing clinician before continuing

pooled comparators found in a meta-analysis covering the whole clinical trial program, and the upper bounds of the confidence intervals for MACE were 8.5% [37]the latter results showing meaningful reductions in both subgroups, but with higher baseline HbA 1c predicting greater reductions