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Gq-mER is present in the hypothalamus and its expression is restricted to NPY/AgRP neurons where it decreases neuronal activity (82, 83, 92)

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Older age, prior heart failure (HF) and CV events, peripheral artery disease, and kidney complications can identify a subgroup of patients with T2D at high risk of mortality who are likely to achieve the greatest benefit from aggressive management of modifiable risk factors and newer glucose-lowering agents