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These biological factors often override behavioral interventions, making weight maintenance challenging without pharmacological support

Behavior change and implementation supports 5.1

Activation of murine preproglucagonproducing neurons reduces food intake and body weight

Furthermore, liraglutide enhances NK cell-mediated cytotoxicity through suppression of the IL-6/STAT3 signaling pathway in HCC cells, thereby promoting immune surveillance (121)

Meanwhile, those who only went through weight loss plans that included diet and exercise and no drugs lost significantly less weight, but took longer to regain it