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Description
Conceptually, GLP-1RAs share pleiotropic effects with exercise one of the few interventions with proven disease-modifying potential by enhancing insulin signaling, stabilizing mitochondria, reducing inflammation, and promoting synaptic plasticity

There is controversy as to whether glucose-induced GLP-1 secretion is disturbed in patients with type-2 diabetes
The data revealed that while participants treated with semaglutide did lose absolute lean mass, they lost a significantly larger amount of fat mass

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Author Affiliations: Henry Ford Health, Center for Healthcare Improvement, Detroit, Michigan (Breitzig)

Effect of liraglutide on expression of inflammatory genes in type 2 diabetes