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6 The studies cited above were conducted using FDA-approved subcutaneous semaglutide

Demand for GLP-1RAs has increased significantly in recent years [See Figure 1], driven primarily by their use for weight-loss purposes rather than for diabetes

Recommendations include a high-fibre diet, increased water intake and increased physical activity (Flowchart 1)

16 A Unique Mechanism Whats particularly intriguing is how allulose triggers GLP-1 release

doi:10.1124/dmd.123.001441 210

Thirty models have been developed to predict pharmacokinetics and physiologically based pharmacokinetic modeling can be useful for assessing mechanism-of-action-mediated DDIs
