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Psychologically, low self-esteem, body image concerns, and social stigma can create emotional distance between partners

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Mice overexpressing 11-HSD1 globally, or specifically in adipose tissue, have a metabolic syndrome phenotype of obesity, dyslipidemia, and glucose intolerance (28)

doi: 10.1038/nrendo.2015.51

However, such approaches often yield limited results, as they fail to address the underlying biological mechanisms driving weight gain