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Last reviewed: June 10, 2026 Last updated: June 10, 2026 Written by: Jay Hastings, CEO of PlexusDx Jay Hastings is the CEO of PlexusDx, a precision health company focused on genetic testing, blood biomarker insights, and personalized wellness recommendations

of these, 650 million individuals are adults

In chronic pain states, TRPV1 channels are upregulated in nociceptive neurons, which lowers stimulation thresholds and increases pain perception, as reported in hyperalgesia or allodynia 21
Kanoski SE, Rupprecht LE, Fortin SM, De Jonghe BC, Hayes MR

Fundamental body composition principles provide context for fat-free and skeletal muscle loss with GLP-1 RA treatments

The FDA allows bulk compounding of prescription medications, which are in shortage, and many Americans are now taking compounded GLP-1 medications
