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Pharmacokinetic comparisons between diabetic individuals and healthy individuals have shown that tirzepatide delays gastric emptying, particularly after a single dose, and demonstrates a decrease in effectiveness or responsiveness with repeated once-weekly dosing, referred to as tachyphylaxis [44, 72]

Table 1 Illustrative case report A 23-year-old man presented with a 2-month history of seeing a discoloured area in both eyes, on a background of longstanding intermittent headache and at least 5 years of pulsatile tinnitus

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Tirzepatide loses potency at room temperature