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Description
These medications work by steady receptor activation, not on-demand use

In a retrospective cohort study including 7,044 patients with T2D, obesity (BMI 27 kg/m 2 ) and HFpEF, combination therapy with an SGLT2i and GLP-1 RA showed a lower risk of HF exacerbation, all-cause emergency department visits and new-onset kidney injury compared with patients only receiving SGLT2i

The upper arm profile becomes more defined, especially for people who combine GLP-1 therapy with resistance training
Pfizer noted that the incidence of elevated liver enzymes with danuglipron was consistent with that observed in approved GLP-1 treatments

This vascular dysfunction may cause the development of cerebral amyloid angiopathy and may contribute to the neurodegenerative processes observed in AD [17]

A phase 2 trial
