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These effects include the reduction of inflammation and oxidative stress, vasodilation, decreased arterial stiffness, and a reduction in myocardial fibrosiskey factors in the pathophysiology of HFpEF

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Oral semaglutide delivered meaningful reductions in HbA1c and body weight among GLP-1RA-nave adults with type 2 diabetes in a Dutch real-world cohort

GLP-1 stimulation induced serine phosphorylation of wild-type GLP-1R, which was abolished in all individual doublet as well as triple doublet phospho-null mutants

Results In established Atherosclerotic Cardiovascular Disease, semaglutide significantly reduces major adverse cardiovascular events
