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To assess heterogeneity, Chi-square and I 2 statistics were utilized, with significant heterogeneity defined as a p -value below 0.1 and an I 2 exceeding 50%

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Glucagon signalling in hepatocytes suppresses intermediaries in fatty acid synthesis and prompts catabolism of FFAs, leading them to beta-oxidation and degradation, thereby diverting them from storage as triglycerides and eventual release in the form of VLDL [72]

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The stress hormone cortisol interferes with sleep quality, promotes muscle breakdown, and directly causes tiredness when chronically elevated

This could mean that there are significantly more individuals using these medications than what is captured here