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In another clinical trial of 140 participants, researchers found that semaglutide medications led to a loss of lean muscle mass in addition to fat loss

Contrave delivered roughly 5-8% body weight reduction over 56 weeks across COR clinical trials

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Thus, better defining the factors that regulate the production and release of GLP1, along with the physiological conditions associated with the rise and fall of GLP1 levels may advance our understanding of GLP1 physiology in metabolic disease

[DOI] [PMC free article] [PubMed] [Google Scholar] 5.Tan SY, Mei Wong JL, Sim YJ, Wong SS, Mohamed Elhassan SA, Tan SH