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However, its angiogenic properties raise legitimate safety considerations, suggesting that indication-specific developmentfavoring acute or localized applicationsmay be more appropriate than chronic systemic exposure

[DOI] [PMC free article] [PubMed] [Google Scholar] 6.Diz-Chaves, Y

But side effects are common when starting treatment or moving up to a higher dose

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[DOI] [PubMed] [Google Scholar] 15.Kaihara K.A., Dickson L.M., Ellenbroek J.H., Orr C.M., Layden B.T., Wicksteed B