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Cognition and mood does chronic appetite suppression alter dopamine tone, motivation, or emotional range

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GLP-1 is also a central regulator of hunger and reward pathways in the brain, which is where its role in addiction is starting to become clearer

Unlike semaglutide (Wegovy, Ozempic), which is dosed weekly, Saxenda requires daily injections and was the first GLP-1 approved specifically for weight loss in non-diabetic patients

For patients with severe renal impairment, dose adjustment or alternative agent selection may be necessary [24]

The team acknowledged that muscle mass loss is not negligible, but the preservation of a greater proportion of lean mass relative to fat is promising