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For example, one clinical trial reported that 15.2 percent of participants experienced headaches after higher-dose semaglutide, compared to 12.2 percent of participants receiving a placebo (an inactive treatment)

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Further electrophysiological study showed that, opposite to the effects on arcuate POMC neurons, GLP-1 hyperpolarizes arcuate NPY neurons indirectly via increased GABA A receptor-mediated neurotransmission of local GABAergic interneurons (Secher et al., 2014