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But the new report suggests that the real-world efficacy is not as promising as clinical trial data would suggest

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Symptom resolution varied with discontinuation or continued therapy

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A peptide isolated from the saliva of a poisonous lizard, Gila monster ( Heloderma suspectum ), native to the US and Mexico shares 50% amino acid sequence identity with human GLP-1

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If you have pre-existing medical conditions such as diabetes, kidney disease, or cardiovascular disease, or if you are taking other medications (such as diuretics, statins, or blood pressure medications) that may increase cramping risk, inform your healthcare provider

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