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Am J Physiol - Regul Integr Comp Physiol (1998) 274(1 43-1):239

Today's oral GLP-1s give 13-15% weight loss at 36 weeks (orforglipron Phase 2)
While nausea rates are lower than semaglutide (28% vs 44%), the dual receptor activation may create unique nutritional considerations that single-receptor agonists do not

As shown in Figure 4

And what that tells you is that digestion doesn't begin here in your mouth

Evelyn Attia, MD, director of the Center for Eating Disorders at NewYork-Presbyterian, says people whove struggled with eating disorders or restrictive dieting should avoid taking GLP-1s
