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Clinical trials show semaglutide produces 15% to 22% body weight reduction when combined with lifestyle changes, a far more dramatic effect than metformin alone

GLP-1 receptor agonists work by slowing gastric emptying and increasing feelings of fullness, which can interact with stimulant-heavy pre-workout formulas

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Gastrointestinal side effects also amplify, potentially leading to severe nausea, vomiting, or inadequate nutrition

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