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FDA in November 2023 under the name Mounjaro, which shows a much larger body weight decrease than semaglutide and similar side effects [81,85]

A recent study found that GLP-1 drugs like Ozempic and Wegovy may significantly reduce blood pressure

[78] revealed that 2550 g/mL Am-EVs in an LPS-induced Caco-2 inflammation model precisely modulated the MAPK signaling cascade through coordinated downregulation of TRIF/MyD88/p38 MAPK/FOS and upregulation of TGFBR2, leading to marked reductions in oxidative stress markers (ROS, MDA), restored catalase activity, and suppressed pro-inflammatory cytokine (TNF-/IL-1/IL-6) expression

Pathways for Intracellular Signaling in the Langerhans Islets GLP- 1 receptor, GIP receptor, and glucagon receptor are mainly expressed on beta, alpha, and delta cells in the islets of Langerhans, where they influence hormone secretion and regulate the survival and proliferation of endocrine cells

For diabetics, these drugs mimic the natural hormone and help lower blood sugar