retatrutide and menstrual cycle : r/RetatrutideWomen Switching from tirzepatide to retatrutide:

doi: 10.1016/S0021-9258(18)96838-9 55 SalemVIzzi-EngbeayaCCoelloCThomasDBChambersESComninosANet al

Missing a dose entirely may cause appetite to return within days as semaglutide levels drop, potentially triggering overeating or cravings

8 GLP-1 is produced by L cells in the lower part of the small intestine and the colon

The sample size for TRIUMPH4 is designed to provide at least 90% power to demonstrate the superiority of retatrutide 9 and 12 mg over placebo on each of the coprimary endpoints: percent change in body weight and percent change in WOMAC pain subscale score (with similar assumptions as above)

however, it remains to be seen if these side effects will be confirmed in larger populations [69, 70]

Hendrikse et al., 2015