why is there a shortage of glp 1 GLP-1 = Over FDA Ends Compounding of GLP-1

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GLP-1 receptor agonists work by mimicking a naturally occurring hormone that regulates appetite and blood sugar

In EMPA-REG OUTCOME, the kidney composite of albuminuria progression, doubling of serum creatinine, end-stage kidney disease (ESKD), or renal death was reduced by 39%, with consistent benefits across multiple subgroups including those with chronic kidney disease (CKD) at baseline [34]

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These studies demonstrate that there is none or very little GLP-1R expression in the renal vasculature and GLP-1-induced renal artery vasodilation leading to increases in renal blood flow and glomerular filtration rate is diminished in spontaneously hypertensive rats [56, 57]