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Change in cardiometabolic risk factors associated with magnitude of weight regain 3 years after a 1year intensive lifestyle intervention in type 2 diabetes mellitus: the Look AHEAD trial

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Small blood vessel damage of the optic nerve, which contributes to glaucoma, may also play a role

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Lifestyle Factors That Override Medication Benefits Semaglutide reduces hunger signals and slows gastric emptying, but it cannot override consistent caloric surplus from high-energy-density foods, frequent snacking, or large portion sizes