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In the first aspect of the second embodiment of the present invention, the conversion in step b) is carried out by cleavage of the peptide chain from the Resin and global deprotection of the amino acids followed by reacting the obtained compound with compound of formula-3

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BV-2 cell culture and treatment BV-2 cells were provided by Procell Life Science & Technology (Wuhan, China)

10.1097/j.pain.0000000000002429 [DOI] [PMC free article] [PubMed] [Google Scholar] Burton G