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Importantly, these criteria intentionally exclude peptide systems for which multiple well-designed human studies have demonstrated a lack of efficacy or unacceptable safety profiles

The first two weeks mark a critical adaptation phase

doi: 10.2337/ds16-0026 Saltiel, A

If you are five weeks into a GLP-1 and wondering whether feeling this queasy is normal, and how much longer it goes on: it is normal, it is the single most common effect of these medicines, and of all the gastrointestinal side effects it is the one that passes fastest