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Reduce glucagon secretion, which helps prevent blood sugar spikes after meals (1,2)

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This is supported by a study showing that re-introduction of GLP-1Rs into the POMC neurons of GLP-1R knockout mice did not reinstate weight loss in lean animals, but partially restored weight loss (~50%) in obese animals (196)

Randomization and treatment Participants were randomly assigned in a 2:1 ratio to receive once-weekly subcutaneous injections of survodutide 6.0 mg (maintenance dose) or placebo (Extended Data Fig

These results are not surprising, given that the role of semaglutide and other GLP-1 analogues in reducing appetite, calorie intake, and consummatory behaviors has been well documented factors that contributed to semaglutides approval for the treatment of obesity (69)

Semaglutides record in both diabetes management and weight reduction has elevated it to blockbuster status, and its designation as an essential medicine has further highlighted the urgency of bringing prices down as barriers fall in much of the world