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A structured taper may help reduce that risk for some patients

Publisher | Google Scholor Mishra SP, Karunakar P, Taraphder S, Yadav H

Turning to another popular GLP-1, Mounjaro (tirzepatide), studies report 20-25% total body weight loss at maximum doses after 72 weeks

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Current FDA labels document these patterns in detail: Wegovy (semaglutide) lists nausea (44% vs 16% placebo), vomiting (25% vs 6%), diarrhea (30% vs 16%), constipation (24% vs 11%), abdominal distension and eructation, with severe GI events in 4.1% versus 0.9% placebo.[2] Zepbound (tirzepatide) lists nausea, diarrhea, vomiting, constipation, abdominal pain, dyspepsia, eructation, and gastroesophageal reflux disease among common adverse reactions, with severe GI disease as a Warnings and Precautions item.[3] Both labels include postmarketing reports of ileus, severe constipation including fecal impaction, and acute kidney injury related to dehydration from severe GI symptoms

[DOI] [PubMed] [Google Scholar] 83.Buse J.B., Wexler D.J., Tsapas A., Rossing P., Mingrone G., Mathieu C., DAlessio D.A., Davies M.J