retatrutide triple agonist glp-1 gip glucagon phase 2 obesity Retatrutide: How the Compares to Tirzepatide Eli Lilly: GLP-1R/GCGR/GIPR Triagonist Reduces
Description
Knudsen LB
doi: 10.1111/obr.13046 143 SetjiTLBrownAJ
Tirzepatide Once Weekly for the Treatment of Obesity AMG 133 is a novel bispecific glucose-dependent insulinotropic polypeptide receptor (GIPR) antagonist and glucagon-like peptide-1 (GLP-1) receptor agonist molecule
Funding SG is supported by a Crohns and Colitis Foundation Career Development Award
In non-obese diabetic (NOD) mice which are a murine model of T1DM, GLP-1RAs can improve immune functions and inflammatory responses as well as mitigating against islet cell damage, an action which may be related to the decrease in the expression of miR-19b [145]
1-3 GLP-1 also binds pancreatic alpha receptors, impeding glucagon synthesis
