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Given levothyroxine's narrow therapeutic index, thyroid function should be reassessed 6-8 weeks after significant weight loss or if persistent gastrointestinal symptoms develop

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Retatrutide is an investigational injectable medicine from Eli Lilly
Similar to adults, serious side effects in pediatric studies were not significant

35 Furthermore, the RCT LIGHT-ON (NCT02147925) compared the effect of liraglutide, sitagliptin and insulin glargine, when added to metformin in diabetic patients, exhibiting statistically significant results, in favor of liraglutide and sitagliptin, regarding body weight, visceral adipose tissue and liver fat content reduction

For some patients, one medication may be more appropriate than the other depending on their health history, treatment goals, and how their body responds to therapy
