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What do GLP-1s actually do in the gut

Supports Weight Loss: Inhibits fat cell growth and promotes fat breakdown, assisting in reducing body weight and preventing weight gain

Del Prato S, Kahn SE, Pavo I, Weerakkody GJ, Yang Z, Doupis J, et al

They found that intestinal flora may mediate the release of the intestinal hormone GLP-1 through the short-chain fatty acid (SCFA)-GPCR pathway, thereby increasing satiety and slowing gastric emptying, ultimately reducing obesity

By the 1970s, one hormone was identified as an incretin candidate: Gastric Inhibitory Polypeptide (GIP) , discovered in 196970, which was found to stimulate insulin secretion (and renamed Glucose-Dependent Insulinotropic Polypeptide ) ( [30] )

GLP-1, or glucagon-like peptide-1, is a naturally occurring hormone that helps regulate appetite, digestion, and insulin release, promoting a sense of fullness after meals