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Similarly, AMPK depletion in intestinal epithelial cells impairs intestinal barrier function and integrity and epithelial cell migration [96] (Figure 2)
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Retatrutide adds the glucagon component, which can contribute to increased heart rate and potential blood glucose fluctuations in some individuals
A potential mechanism is via GLP-1, which alters gastrointestinal transit, gastric accommodation (45, 46, 63), and has direct effects on hypothalamic nuclei outside of the bloodbrain barrier (64)
doi: 10.1016/j.healun.2024.02.1019
Ozempic vs Wegovy: Breaking Down the Key Differences
