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We confirmed the robustness of our findings for the composite outcomes, as complementary analyses using both a Fine-Gray model and a cause specific hazard model with time varying inverse probability-of-death censoring weights yielded consistent results on both relative and absolute scales (supplementary figures S5 and S7)

Meta-analysis assessing the effectiveness of SGLT2i+GLP1RA combination therapy versus monotherapy on cardiovascular and cerebrovascular outcomes in diabetic patients

It activates G-protein coupled receptors FFAR2 and FFAR3 on L cells, triggering calcium influx and subsequent GLP-1 vesicle release

Clearly positive for patients, especially those with high out-of-pocket costs

While in SUSTAIN-6, a sharper decline (46%) in macroalbuminuria seems to be entirely due to the semaglutide treatment than a 26% fall in macroalbuminuria by liraglutide [22]