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Follow-up support: Check-ins focused on tolerance, progress, appetite changes, and practical next steps

Researchers studying semaglutide used 1 mg doses, while researchers for tirzepatide used a dose of 2.4 mg

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Tirzepatide is a synthetic peptide belonging to the class of dual incretin receptor agonists, designed to interact with both the glucose-dependent insulinotropic polypeptide (GIP) receptor and the glucagon-like peptide-1 (GLP-1) receptor [1]

reintroduce a varied diet as symptoms improve For constipation: Gradually increase dietary fibre through vegetables, fruit, and wholegrains Ensure adequate fluid intake throughout the day Light physical activity, such as walking after meals, can stimulate bowel motility For diarrhoea: Temporarily reduce high-fibre or high-fat foods Avoid artificial sweeteners (sorbitol, xylitol), which have a laxative effect [23] Rehydrate carefully with water or, if needed, oral rehydration salts (ORS) solutions (available from pharmacies), which are more appropriate than general sports or electrolyte drinks for replacing fluid and electrolytes lost through diarrhoea For people with diabetes: If you are taking insulin or a sulfonylurea alongside retatrutide, reduced appetite and food intake may increase your risk of hypoglycaemia (low blood glucose)