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Antagonism of gastric inhibitory polypeptide (GIP) by palmitoylation of GIP analogues with N- and C-terminal modifications improves obesity and metabolic control in high fat fed mice

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Advantage : Neither (tie) Weight Loss Efficacy# CagriSema : REDEFINE 1 Phase 3 demonstrated 20.4% mean weight loss at 68 weeks

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By 8 mg, the weight-loss curve has reached about 94% of the 12 mg result because the downstream response approaches its ceiling before receptor occupancy does