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Description
Patients with CS show phenotypical characteristics including moon face, facial plethora, striae rubrae, supraclavicular and dorsal fat pads (86) and several comorbidities including DM, visceral obesity dyslipidaemia, cardiovascular disease, osteoporosis and vertebral fractures, infections and neuropsychiatric disorders, which can sometimes persist even after the disease is cured and contribute to increased mortality, compared to the general population (87, 88)

Fissures are usually visible on examination and respond well to conservative measures such as stool softeners, topical treatments, and sitz baths

But with split dosing, a missed dose disrupts the concentration profile more quickly because there is less drug in reserve from each individual injection

If your vial spends time in a hot car, near a window in direct sunlight, or in any environment above 86 degrees Fahrenheit, the semaglutide begins degrading

Your provider should discuss these factors before treatment initiation to align expectations with your biology

GLP-1 is secreted by L-cells located primarily in the lower small intestine and colon, explains Patricia Bannan, RDN, a registered dietitian in Los Angeles, California
