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These include: Pre-existing constipation or slow transit constipation Inadequate dietary fibre intake Insufficient fluid consumption Reduced physical activity levels Concurrent medications with constipating effects (such as opioids, certain antidepressants, or iron supplements) Older age , where baseline colonic motility may already be reduced The severity of constipation often correlates with the dose of medication and may be more pronounced during dose escalation phases

The role of endothelial nitric oxide in the anti-restenotic effects of liraglutide in a mouse model of restenosis

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They lie just outside the epithelial cells that make up blood vessels and in the areas surrounding the nerves and myocytes

A systematic review published in Current Treatment Options in Psychiatry analyzed 81 human and animal studies and concluded that GLP-1 receptor agonists showed potential benefits for depressive symptoms, anxiety, cognitive function, binge eating, and alcohol or substance use disorders (3 Trusted Source The Impact of GLP-1 Receptor Agonists (GLP-1 RAs) on Mental Health: A Systematic Review Go to source)