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found that intragastric administration of L

4 A history of gallbladder disease A 2022 systematic review of 76 randomised trials found that GLP-1 medications are associated with a relative risk of around 37% for gallbladder or biliary disease, with a higher relative risk in weight-loss trials than in diabetes trials

Tirzepatide is given as a once-weekly subcutaneous injection, meaning its injected into the fatty tissue just under the skin typically in the abdomen, thigh, or upper arm

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CCK is released by the small intestine in response to the presence of fat and protein

10.1210/clinem/dgaa285 J Clin Endocrinol Metab