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Its development is unusual among modern peptides in that the compound is the end point of a documented, four-decade scientific chain: from the sequencing of a gene, through the identification of a physiological hormone, to a specific set of chemical modifications engineered to solve a well-defined pharmacokinetic problem

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After several studies showed it to have a significant impact on weight loss as well, the FDA-approved semaglutide for use for patients with obesity

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Pennsylvania has obesity rates that track near and sometimes above the national average, with meaningful variation between the Philadelphia and Pittsburgh metros and the rural central and northern parts of the state