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Retatrutide's novel triple-agonist approach produced 28.7% weight loss in Phase 3 TRIUMPH-4 (confirming 24.2% in Phase 2) by adding glucagon and GIP receptor activation

Metabolic Flexibility GIP and glucagon receptor activation complements GLP-1 appetite suppression with enhanced energy expenditure and improved lipid metabolism signalling

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Adjusting as weight stabilizes During active weight loss, nutrient demands peak

Better Cardiometabolic Health Addressing multiple risk factors simultaneously may help reduce overall cardiovascular risk