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Gut 2012

Of course, when appetite increases, dieting can become very difficult

Zhang T, Cheng JK, Hu YM
Lower doses may reduce GI side effects for some people, but may also reduce therapeutic benefit

Notably, an accelerating decline in male reproductive parameters has been observed over recent decades, with some reports suggesting that average sperm count and sperm concentration have fallen by more than 50% worldwide
But gastroparesis, a condition where the stomach loses its ability to empty properly, was not prominently warned about
