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Semaglutide (Wegovy) a GLP-1 receptor agonist with demonstrated significant and sustained weight reduction in clinical trials

doi: 10.2337/db16-1344

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The pharmacologic GLP-1RA semaglutide has been shown to bind GLP-1R with higher affinity than GLP-1 [76] and achieve nanomolar concentrations with pharmacologic interventions [77], suggesting that exogenous GLP-1R therapy may induce PKA-associated insulin secretion in pancreatic tissue that is not achieved with physiologic GLP-1 activity