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If we can actually get this drug into our patients, we are going to see an even more profound reduction in the epidemiology of CKD that was kick-started by RAS inhibitors 2 decades ago and amplified by flozination in the last few years.

Potent agents like tirzepatide produced the largest total weight loss figures and the steepest absolute lean mass reductions alongside them

When I first started taking it, I was very tired, had no appetite, and felt quite nauseous

Prebiotics under the fermentation of gut microbiota could increase gut peptide production, such as GLP-1 and PYY (75)
Injection site redness may appear and resolve within 24 to 48 hours

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