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A related concern is the body composition consequence of rebound: GLP-1 RA-induced weight loss includes a proportional loss of fat-free mass, and weight regained after discontinuation returns disproportionately as fat a sarcopenic recomposition pattern that is physiologically expected during weight cycling and is only now being formally quantified in the GLP-1 RA context (Tinsley & Heymsfield, 2024)

doi:10.1161/circheartfailure.118.004905 Salazar, M

Additionally, they offer benefits like improved metabolism, cardiovascular health, and kidney health

Therefore, our observations suggest that activation of GLP-1-receptor axis by LINA could increase the USE via reducing ENaC and p-Nedd4-2 levels in the kidneys of DKD rats