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When Side Effects Require Medical Attention Severe or persistent vomiting, signs of dehydration (dark urine, dizziness, extreme thirst), or signs of pancreatitis (severe upper abdominal pain radiating to the back, fever) require immediate medical attention

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Other factors worth considering include: Meal timing : As a pragmatic measure (not an evidence-based recommendation), some patients find that avoiding injection immediately before a large meal helps reduce gastrointestinal discomfort, consistent with general advice for incretin-based therapies

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Cardio- and reno-protective effects are unlikely to be solely explained by the mechanisms used by these drugs to lower blood glucose levels, as the same effects are not seen with drugs that have stronger antihyperglycaemic actions [111], and were not dependent upon the degree of HbA1c reduction [113,114,115]

This article breaks down the science, clinical trial results, and real-world experiences with these medications to help you understand their role in weight loss