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Tirzepatide and semaglutide are well-known names, mostly due to their effectiveness for weight loss

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Among the marketed large molecule injectable GLP-1 agonists, semaglutide, apart from weight-loss, is being studied for kidney disease and tirzepatide (a dual GLP-1 and GIP receptor agonist) is being evaluated for sleep apnea in Ph 3 clinical trials

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In patients with diabetes mellitus not achieving targets on lifestyle measures, pharmacologic therapy should be considered
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