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Three leptin-deficient adults with a missense mutation of the leptin gene were evaluated during treatment with recombinant methionyl human leptin (r-metHuLeptin), and the therapy was found decrease insulin resistance (Paz-Filho et al., 2008a)

doi:10.1111/j.1360-0443.2012.04054.x Jonas DE, Amick HR, Feltner C, et al

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