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PubMedPMC 30

Keep an eye out in early 2026 as this is expected to debut soon

The pathophysiology of diabetic nephropathy is mainly due to the enhanced glucose uptake in tubule cells via SGLT2 inducing oxidative stress, expression of inflammatory and fibrosis genes, and increased apoptosis (Figure 2) [85,86]

GLP-1 is a strong mediator of somatostatin release from delta cells [61,62,63,64], and blocking the effects of somatostatin with a somatostatin receptor 2 antagonist diminishes the inhibitory action of GLP-1 in the rat pancreas [61,64]

Ozempic is a medication approved for adults with type 2 diabetes

Patients tolerating once-daily GLP-1 receptor agonist therapy at the maximal therapeutic dose should start a once-weekly GLP-1 receptor agonist the day after their last dose of once-daily medication
