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These subcutaneous injections are typically self-administered once weekly at home or at a medical spa under nurse or doctor supervision

doi: 10.2337/diabetes.54.2.482 [DOI] [PubMed] [Google Scholar] 37

After three months, they lost 14 pounds, or 6% of their body weight, on average

The trade-off is that careful dosing and monitoring are especially important to keep side effects manageable

Berberine improves insulin resistance and therefore, improves energy expenditure and may reduce body weight

This medication should not be used by people with a personal/family history of a certain type of cancer (medullary thyroid carcinoma) or by people with a certain inherited disease (Multiple Endocrine Neoplasia syndrome type 2 or MEN 2)
